Scottish study does not replicate findings

To replicate or not to replicate: the case of pharmacogenetic studies: Establishing validity of pharmacogenomic findings: from replication to triangulation.

Reality Does Not Recognize Borders

Reality does not recognize borders. Why we should use the very general term of “reality” and not science, because the borders that we draw are pure delusions, and on the opposite side there is the reality. The laws of the universe, either the physical nature of the world which the scientist studies or metaphysics which is the territory of philosophers, it isthe same reality that rules. Today ma...

Discovering findings that replicate from a primary study of high dimension to a follow-up study

We consider the problem of identifying whether findings replicate from one study of high dimension to another, when the primary study guides the selection of hypotheses to be examined in the follow-up study as well as when there is no division of roles into the primary and the follow-up study. We show that existing meta-analysis methods are not appropriate for this problem, and suggest novel me...

HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28.

In this report, we demonstrate that the T cell tropic strain of HIV, LAI, does not replicate in naive CD4 T cells stimulated by cross-linking CD3 and CD28. In contrast, LAI replicates well in memory CD4 T cells stimulated in the same way. Unlike this physiologically relevant stimulation, PHA stimulates productive LAI replication in both naive and memory T cells. These studies were conducted wit...

The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Does Not Replicate in Syrian Hamsters

In 2012 a novel coronavirus, MERS-CoV, associated with severe respiratory disease emerged in the Arabian Peninsula. To date, 55 human cases have been reported, including 31 fatal cases. Several of the cases were likely a result of human-to-human transmission. The emergence of this novel coronavirus prompts the need for a small animal model to study the pathogenesis of this virus and to test the...